Human Duet siRNA Library - Genome - Set of 4

Duet siRNA Libraries are paired libraries of siGENOME and ON-TARGETplus siRNA SMARTpool reagents. The Human Duet Genome siRNA Library targets all unique human genes (NM Accession numbers) in the RefSeq database. Genome-wide siRNA screening has become an invaluable discovery tool, and siRNA products are more often the choice for high quality, reliable screening libraries.

Highlights
Increase confidence in your RNAi screen with two guaranteed, highly functional SMARTpool siRNA reagents (see Figure 1, Supporting Data tab)
Screen the libraries side-by-side to move high confidence hits through the pipeline faster (see Figure 2, Supporting Data tab)
Use the libraries separately as a cost-effective way to obtain two guaranteed collections of highly potent siRNA reagents

siRNA Designs
Both siGENOME and ON-TARGETplus siRNA reagents utilize the same SMARTselection foundational elements for highly-functional designs. ON-TARGETplus designs are additionally filtered for specificity-enhancing features that improve the potential for unique designs.

In 30% of genes (across the human genome), all eight siRNA sequences targeting a single gene are unique.
Only 5% of genes share four siRNA sequences across both product lines.
Even in cases of identical designs, it has been widely demonstrated that ON-TARGETplus specificity-enhancing modifications provide distinct and reduced off-target signatures and thus can be treated as unique silencing reagents.