Pre-designed siRNA reagents for effective knockdown of human long noncoding RNA (lncRNA). Expert siRNA design and specificity-enhancing modifications for high-confidence RNAi results.
Highlights
Pre-designed against 5867 characterized lncRNAs (NR_ and XR_ transcripts) in Human RefSeq v.65
Lincode siRNAs carry proprietary dual-strand chemical modifications to ensure optimal strand loading for the reduction of off-targets
SMARTpool reagent technology that targets multiple regions of the lncRNA to improve the likelihood of RNAi-mediated degradation
The importance of high-confidence siRNA reagents in lncRNA knockdown studies
lncRNA may be more difficult to silence than protein-coding genes due to:
Nuclear localization of the lncRNA, reducing availability to RNAi cellular machinery
Tertiary structure of the lncRNA, preventing siRNA access to the target region
DNA or protein binding to the lncRNA, preventing siRNA access to the target region
Available Product Formats
SMARTpool: A mixture of 4 siRNA provided as a single reagent; providing advantages in both potency and specificity.
Set of 4: Discounted price on the Set of 4 siRNAs targeting a single gene. NO PRIOR PURCHASE REQUIRED.
Individual siRNAs: Select 1, 2, or 3 individual siRNAs per gene. Minimum purchase of four at the 2 nmol size.
