RABBIT ANTI 14-3-3 ZETA/DELTA

Rabbit anti Human 14-3-3 zeta/delta antibody recognizes the 14-3-3 zeta/delta, also known as 14-3-3 protein/cytosolic phospholipase A2, protein kinase C inhibitor protein 1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein-delta polypeptide, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide.

The YWHAZ gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for YWHAZ (provided by RefSeq, Oct 2008).

Rabbit anti Human 14-3-3 zeta/delta antibody detects a band of 28 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.