RABBIT ANTI ADD1

Rabbit anti Human ADD1 antibody recognizes alpha-adducin, also known as alpha-adducin, ADD1 or ADDA.

Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described (provided by RefSeq, Jul 2008).

Rabbit anti Human ADD1 antibody detects a band of 120 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.