RABBIT ANTI AIRE

Rabbit anti Human AIRE antibody recognizes AIRE, also known as autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein.

AIRE encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in AIRE cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED) (provided by RefSeq, Jun 2012).

Rabbit anti Human AIRE antibody detects a band of 58 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.