RABBIT ANTI ALK1

Rabbit anti Human ALK1 antibody recognizes serine/threonine-protein kinase receptor R3, also known as ACVRLK1.

The ACVRL1 gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in ACVRL1 are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 (provided by RefSeq, Jul 2008).

Rabbit anti Human ALK1 antibody detects a band of 56 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.