RABBIT ANTI ALPHA ACTININ-1

Rabbit anti Human alpha actinin-1 antibody recognizes alpha-actinin-1, also known as F-actin cross-linking protein, actinin 1 smooth muscle and alpha-actinin cytoskeletal isoform.

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. ACTN1 encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for ACTN1 (provided by RefSeq, Jul 2008).

Rabbit anti Human alpha actinin-1 antibody detects a band of 100 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.