RABBIT ANTI APBB1

Rabbit anti Human APBB1 antibody recognizes APBB1, also known as FE65, adaptor protein FE65a2 and amyloid beta A4 precursor protein-binding family B member 1.

The protein encoded by the APBB1 gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants encoding different isoforms have been described for APBB1 (provided by RefSeq, Mar 2012).

Rabbit anti Human APBB1 antibody detects a band of 107 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.