RABBIT ANTI APOLIPOPROTEIN E

Rabbit anti Human apolipoprotein E antibody recognizes apolipoprotein E, also known as apolipoprotein E3, APOE, APO-E, or LPG.

Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants (provided by RefSeq, Jul 2008).

Rabbit anti Human apolipoprotein E antibody detects a band of 35 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.