RABBIT ANTI ARHGDIB

Rabbit anti Human ARHGDIB antibody recognizes the Rho GDP-dissociation inhibitor 2, also known as Rho GDI 2, rho GDP-dissociation inhibitor 2, or rho-GDI beta.

Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (et al. 1993).

Rabbit anti Human ARHGDIB antibody detects a band of 27 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.