RABBIT ANTI AUP1

Rabbit anti Human AUP1 antibody recognizes the ancient ubiquitous protein 1.

AUP1 encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by AUP1 has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. AUP1 overlaps the gene for mitochondrial serine protease 25 (provided by RefSeq, Jul 2008).

Rabbit anti Human AUP1 antibody detects a band of 42 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.