RABBIT ANTI BETA-CENTRACTIN

Rabbit anti Human beta-centractin antibody recognizes beta-centractin also known as actin-related protein 1B or ACTR1B.

The ACTR1B gene encodes a 42.3 kDa subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kDa. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like ACTR1A, is an actin-related protein. These two proteins, which are of equal length and share 90% amino acid identity, are present in a constant ratio of approximately 1:15 in the dynactin complex (provided by RefSeq, Aug 2008).

Rabbit anti Human beta-centractin antibody detects a band of 42 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.