RABBIT ANTI CD172a

Rabbit anti Human CD172a antibody recognizes CD172a, also known as CD172 antigen-like family member A, inhibitory receptor SHPS-1, macrophage fusion receptor, myd-1 antigen and tyrosine phosphatase SHP substrate 1.

The protein encoded by SIRPA is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. SIRPA and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for SIRPA (provided by RefSeq, Jul 2008).

Rabbit anti Human CD172a antibody detects a band of 85 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.