RABBIT ANTI CD324

Rabbit anti Human CD324 antibody recognizes cadherin-1, also known as CAM 120/80, E-cadherin, epithelial cadherin, calcium-dependent adhesion protein-epithelial and uvomorulin.

CDH1 is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in CDH1 are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites (provided by RefSeq, Jul 2008).

Rabbit anti Human CD324 antibody detects a band of 135 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.