RABBIT ANTI CD331

Rabbit anti Human CD331 antibody recognizes CD331, also known as FMS-like tyrosine kinase 2, basic fibroblast growth factor receptor 1, heparin-binding growth factor receptor, hydroxyaryl-protein kinase and proto-oncogene c-Fgr. CD331, encoded by the FGFR1 gene, is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution.

FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction.

Mutations in the CD331 gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving the CD331 gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized (provided by RefSeq, Jul 2008).

Rabbit anti Human CD331 antibody detects a band of 92 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.