RABBIT ANTI CD87

Rabbit anti Human CD87 antibody recognizes CD87, also known as urokinase plasminogen activator surface receptor, monocyte activation antigen Mo3 or u-plasminogen activator receptor form 2,

The PLAUR gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, is likely influence many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types (Stephens et al. 1997). Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined (provided by RefSeq, Jul 2008).

Rabbit anti Human CD87 antibody detects a band of 50 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.