RABBIT ANTI CDK2

Rabbit anti Human CDK2 antibody recognizes cyclin-dependent kinase 2, also known as cdc2-related protein kinase, cell division protein kinase 2 and p33 protein kinase.

The protein encoded by CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products ofS. cerevisiae cdc28, andS. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of CDK2 have been reported (provided by RefSeq, Jul 2008).

Rabbit anti Human CDK2 antibody detects a band of 33 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.