RABBIT ANTI CELF1

Rabbit anti Human CELF1 antibody recognizes the CUGBP Elav-like family member 1, also known as CUG binding protein 1, 50 kDa nuclear polyadenylated RNA-binding protein, bruno-like protein 2, embryo deadenylation element binding protein and nuclear polyadenylated RNA-binding protein, 50 kDa.

Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. CELF1 may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms (provided by RefSeq, Jul 2008).

Rabbit anti Human CELF1 antibody detects a band of 52 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.