RABBIT ANTI COP9 SIGNALOSOME SUBUNIT 6

Rabbit anti Human COP9 signalosome subunit 6 antibody recognizes the COP9 signalosome complex subunit 6, also known as COP9 constitutive photomorphogenic homolog subunit 6, COP9 subunit 6 (MOV34 homolog, 34 kD), JAB1-containing signalosome subunit 6, CSN6 or vpr-interacting protein.

The protein encoded by COPS6 gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr (provided by RefSeq, Jul 2008).

Rabbit anti Human COP9 signalosome subunit 6 antibody detects a band of 36 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.