RABBIT ANTI CYCLOPHILIN A

Rabbit anti Human cyclophilin A antibody recognizes cyclophilin A, also known as PPIase A, T cell cyclophilin, cyclosporin A-binding protein, peptidyl-prolyl cis-trans isomerase A and rotamase A.

PPIA encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported (provided by RefSeq, Jul 2008).

Rabbit anti Human cyclophilin A antibody detects a band of 18 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.