RABBIT ANTI CYCLOPHILIN B

Rabbit anti Human cyclophilin B antibody recognizes cyclophilin B also known as peptidyl-prolyl cis-trans isomerase B, PPIB, PPIase B, S-cyclophilin, cyclophilin-like protein, epididymis secretory protein Li 39, peptidyl-prolyl cis-trans isomerase B, rotamase B or SYP-S1.

The protein encoded by PPIB gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporin A-mediated immunosuppression (provided by RefSeq, Oct 2009). Mutations in the PBIB gene lead to development of Osteogenesis imperfecta 9 (OI9) , a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma (van Dijk et al. 2009).

Rabbit anti Human cyclophilin B antibody detects a band of 20 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.