RABBIT ANTI CYTOKERATIN 8

Rabbit anti Human cytokeratin 8 antibody recognizes cytokeratin 8, also known as keratin 8, keratin, type II cytoskeletal 8 and type-II keratin Kb8.

The KRT8 gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of KRT8, cytokeratin 8 typically dimerizes with cytokeratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in KRT8 cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for KRT8 (provided by RefSeq, Jan 2012).

Rabbit anti Human cytokeratin 8 antibody detects a band of 55 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.