RABBIT ANTI DDX39B

Rabbit anti Human DDX39B antibody recognizes DDX39B, also known as DEAD-box helicase 39B, 56 kDa U2AF65-associated protein, UAP56, ATP-dependent RNA helicase p47, HLA-B-associated transcript 1 protein, nuclear RNA helicase (DEAD family) and spliceosome RNA helicase BAT1.

The DDX39B gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. DDX39B belongs to a cluster of genes localized in the vicinity of the genes encoding tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. Mutations in DDX39B may be associated with rheumatoid arthritis. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on both chromosomes 6 and 11. Read-through transcription also occurs between DDX39B and the upstream ATP6V1G2 (ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2) gene (provided by RefSeq, Feb 2011).

Rabbit anti DDX39B antibody detects a band of 49 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.