RABBIT ANTI DYNACTIN 2

Rabbit anti Human dynactin 2 antibody recognizes dynactin 2, also known as dynamitin, epididymis secretory protein Li 77 and p50 dynamitin.

The dynactin 2 gene encodes a 50 kDa subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kDa. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for dynactin 2 (provided by RefSeq, May 2012).

Rabbit anti Human dynactin 2 antibody detects a band of 44 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.