RABBIT ANTI EIF2AK2

Rabbit anti Human EIF2AK2 antibody recognizes EIF2AK2, also known as P1/eIF-2A protein kinase, double stranded RNA activated protein kinase, eIF-2A protein kinase 2, interferon-induced double-stranded RNA-activated protein kinase, interferon-inducible elF2alpha kinase and tyrosine-protein kinase EIF2AK2.

The protein encoded by EIF2AK2 is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for EIF2AK2 (provided by RefSeq, Oct 2011).

Rabbit anti Human EIF2AK2 detects a band of 74 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.