RABBIT ANTI ERYTHROPOIETIN RECEPTOR

Rabbit anti Human erythropoietin receptor antibody recognizes the erythropoietin receptor also known as EPO-R and EPOR.

The erythropoietin receptor is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates JAK2 tyrosine kinase which activates different intracellular pathways including Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of the erythropoietin receptor may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants (provided by RefSeq, May 2010).

Rabbit anti Human erythropoietin receptor antibody detects a band of 55 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.