RABBIT ANTI FILAMIN-B

Rabbit anti Human filamin-B antibody recognizes filamin-B, also known as ABP-280 homolog, actin binding protein 278, actin-binding-like protein, beta-filamin or SCT.

The FLNB gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in FLNB have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for FLNB (provided by RefSeq, Nov 2009).

Rabbit anti Human filamin-B antibody detects a band of 280 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.