RABBIT ANTI G3BP1

Rabbit anti Human G3BP1 antibody recognizes G3BP1 also known as, Ras GTPase-activating protein-binding protein 1, ATP-dependent DNA helicase VIII, G3BP-1, GAP SH3 domain-binding protein 1, GAP binding protein, Ras-GTPase-activating protein SH3-domain-binding protein or RasGAP-associated endoribonuclease G3BP.

G3BP1 gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of G3BP1 have been described, but the full-length nature of some of these variants has not been determined (provided by RefSeq, Jul 2008).

Rabbit anti Human G3BP1 antibody detects a band of 68 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.