RABBIT ANTI HISTONE ACETYLTRANSFERASE 1

Rabbit anti Human histone acetyltransferase 1 antibody recognizes histone acetyltransferase 1, also known as histone acetyltransferase type B catalytic subunit.

Encoded by the HAT1 gene, histone acetyltransferase 1 is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for HAT1 (provided by RefSeq, Jun 2009).

Rabbit anti Human histone acetyltransferase 1 antibody detects a band of 49 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.