RABBIT ANTI hnRNP H1

Rabbit anti Human hnRNP H1 antibody recognizes heterogeneous nuclear ribonucleoprotein H1 (hnRNP H1).

Encoded by the HNRNPH1 gene, hnRNP H1 is a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hn RNPs). The hn RNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by the hnRNP H1 gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. HNRNPH1 may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described (provided by RefSeq, Mar 2012).

Rabbit anti Human hnRNP H1 antibody detects a band of 50 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.