RABBIT ANTI INTERLEUKIN-21

Rabbit anti Human interleukin-21 antibody recognizes interleukin-21 (IL-21), also known as Za11. IL-21 is a 133 amnio acid ~ 17 kDa immunoregulatory cytokine.

The IL21 gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of IL21 plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Mutation of the IL21 gene causes Immunodeficiency, common variable, 11 (CVID11), a condition characterized by antibody and the inability to mount an antibody response to antigen leading to recurrent bacterial infections (Salzar et al. 2014).Alternatively spliced transcript variants encoding multiple isoforms have been observed for IL21 (provided by RefSeq, Dec 2011).

Rabbit anti Human interleukin-21 antibody detects a band of 17 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.