Rabbit anti Human JAB1 antibody recognizes JAB1 also known as COP9 signalosome complex subunit 5, COPS5, 38 kDa Mov34 homolog, COP9 constitutive photomorphogenic homolog subunit 5, jun activation domain-binding protein 1 or signalosome subunit 5.
The protein encoded by the COPS5 gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUP1 transcription factors (provided by RefSeq, Jul 2008).
Rabbit anti Human JAB1 antibody detects a band of 37 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
