RABBIT ANTI KDELR1

Rabbit anti Human KDELR1 antibody recognizes KDELR1, also known as ER lumen protein retention receptor 1 and putative MAPK-activating protein PM23.

Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetra-peptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor is encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by the KDELR1 gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product (provided by RefSeq, Jul 2008).

Rabbit anti Human KDELR1 antibody detects a band of 28 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.