RABBIT ANTI LAMIN B2

Rabbit anti Human lamin B2 antibody recognizes lamin B2.

The LMNB2 gene encodes a B type nuclear lamin. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Mutations in LMNB2 are associated with acquired partial lipodystrophy (provided by RefSeq, May 2012).

Rabbit anti Human lamin B2 antibody detects a band of 68 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.