RABBIT ANTI MAP3K8

Rabbit anti Human MAP3K8 antibody recognizes MAP3K8 also known as mitogen-activated protein kinase kinase kinase 8, Ewing sarcoma transformant, proto-oncogene c-Cot or tumor progression locus 2.

The MAP3K8 gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. MAP3K8 may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein (provided by RefSeq, Sep 2011).

Rabbit anti Human MAP3K8 antibody detects a band of 53 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.