RABBIT ANTI MAPK1

Rabbit anti Human MAPK1 antibody recognizes MAP kinase 1, also known as mitogen-activated protein kinase 1 or MAP kinase isoform p42.

The protein encoded by MAPK1 is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for MAPK1 (provided by RefSeq, Jul 2008).

Rabbit anti Human MAPK1 antibody detects bands at 42 and 44 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.