RABBIT ANTI MED17

Rabbit anti Human MED17 antibody recognizes MED17 also known as, mediator of RNA polymerase II transcription subunit 17, activator-recruited cofactor 77 kDa component, cofactor required for Sp1 transcriptional activation, subunit 6, thyroid hormone receptor-associated protein complex 80 kDa component, transcriptional coactivator CRSP77 or vitamin D3 receptor-interacting protein complex 80 kDa component.

The activation of gene transcription is a multistep process triggered by factors that recognize transcriptional enhancer sites in DNA, these factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by MED17 gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors (provided by RefSeq, Jul 2008).

Rabbit anti Human MED17 antibody detects a band of 95 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.