RABBIT ANTI MMP-14 HEMOPEXIN

Rabbit anti Human MMP-14 hemopexin antibody recognizes the matrix metalloproteinase-14, also known as membrane type 1 metalloprotease, binding to the hemopexin domain.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by MMP14 gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion (provided by RefSeq, Jul 2008).

Rabbit anti Human MMP-14 hemopexin antibody detects a band of 65 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.