RABBIT ANTI MNAR

Rabbit anti Human MNAR antibody recognizes modulator of non-genomic activity of estrogen receptor, otherwise known as proline-, glutamic acid-, and leucine-rich protein-1.

A product of the MNAR (PELP1) gene, this protein is a novel steroid co-activator of the estrogen receptor (ER) which plays a role in E2-mediated cell cycle progression through interaction with the pRb pathway. MNAR acts as a transcriptional corepressor for nuclear receptors and can interact with chromatin-modifying complex components CBP (CRE-binding protein), histone deacetylase 2 and MTA (metastasis-associated protein)1. Other properties of MNAR include interaction with PI3K, STAT3, and EGF, and SH2-binding which modulates the interaction of the ER to c-Src, leading to MAPK activation. Studies have shown the deregulation of MNAR in breast tumours and endometrial cancers.

Rabbit anti Human MNAR antibody detects a band of 160 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.