RABBIT ANTI MTA1

Rabbit anti Human MTA1 antibody recognizes the metastasis-associated protein MTA1, also known as metastasis associated gene 1 protein.

The MTA1 gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of MTA1 has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70 kDa component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of MTA1 product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. Two transcript variants encoding different isoforms have been found for MTA1 (provided by RefSeq, Feb 2011).

Rabbit anti Human MTA1 antibody detects a band of 76 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.