RABBIT ANTI NEDD4L

Rabbit anti Human NEDD4L antibody recognizes NEDD4L, also known as E3 ubiquitin ligase NEDD4-like and ubiquitin-protein ligase Rsp5.

The NEDD4L gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The NEDD4L protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in NEDD4L may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for NEDD4L (provided by RefSeq, Mar 2012).

Rabbit anti Human NEDD4L antibody detects a band of 135 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.