RABBIT ANTI NPM

Rabbit anti Human NPM antibody recognizes NPM, also known as nucleophosmin, nucleolar protein NO38 or nucleophosmin/nucleoplasmin family, member 1.

This gene encodes a phosphoprotein which moves between the nucleus and the cytoplasm. The gene product is thought to be involved in several processes including regulation of the ARF/p53 pathway. A number of genes are fusion partners have been characterized, in particular the anaplastic lymphoma kinase gene on chromosome 2. Mutations in this gene are associated with acute myeloid leukemia. More than a dozen pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants (provided by RefSeq, Nov 2009).

Rabbit anti Human NPM detects a band of 38 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.