RABBIT ANTI PDLIM7

Rabbit anti Human PDLIM7 antibody recognizes PDLIM7, also known as LIM domain protein, LMP, Lim mineralization protein 3 or protein enigma.

The protein encoded by PDLIM7 gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of PDLIM7 results in multiple transcript variants (provided by RefSeq, Jul 2008).

Rabbit anti Human PDLIM7 antibody detects a band of 50 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.