Rabbit anti Human polyadenylate-binding nuclear protein 1 antibody recognizes polyadenylate-binding protein 1, also known as poly(A) binding protein 1, OPMD and PABPN1.
PABPN1 encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. PABPN1 contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between PABPN1 and the neighboring upstream BCL2-like 2 (BCL2L2) gene (provided by RefSeq, Dec 2010).
Rabbit anti Human polyadenylate-binding protein 1 antibody detects a band of 50 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.
