RABBIT ANTI PRESENILIN-1

Rabbit anti Human presenilin-1 antibody recognizes presenilin-1 also known as PSEN1.

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (presenilin-1 or presenilin-2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for Presenilin-1, the full-length nature of only some have been determined (provided by RefSeq, Aug 2008).

Rabbit anti Human presenilin-1 antibody detects a band of 55 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.