RABBIT ANTI PSMA1

Rabbit anti Human PSMA1 antibody recognizes the proteasome subunit alpha type-1, also known as 30 kDa prosomal protein, PROS-30, macropain subunit nu, multicatalytic endopeptidase complex subunit C2 and proteasome subunit nu.

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMA1 encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms (provided by RefSeq, Jan 2009).

Rabbit anti Human PSMA1 antibody detects a band of 30 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.