RABBIT ANTI PSMB7

Rabbit anti Human PSMB7 antibody recognizes the proteasome subunit beta type-7, also known as macropain chain Z, multicatalytic endopeptidase complex chain Z, proteasome catalytic subunit 2 or proteasome subunit Z.

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. A pseudogene of PSMB7 is located on the long arm of chromosome 14 (provided by RefSeq, Jul 2012).

Rabbit anti Human PSMB7 antibody detects a band of 28 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.