RABBIT ANTI PSMB9

Rabbit anti Human PSMB9 antibody recognizes proteasome subunit beta type-9, also known as large multifunctional peptidase 2, low molecular mass protein 2, macropain chain 7, multicatalytic endopeptidase complex chain 7, proteasome catalytic subunit 1i, proteasome chain 7, proteasome subunit beta 6i or proteasome subunit beta-1i.

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PSMB9 gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. PSMB9 is located in the class II region of the MHC (major histocompatibility complex). Expression of PSMB9 is induced by gamma interferon and PSMB9 product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit (provided by RefSeq, Mar 2010).

Rabbit anti Human PSMB9 antibody detects a band of 23 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.