RABBIT ANTI RAE1

Rabbit anti Human RAE1 antibody recognizes RAE1, also known as mRNA export factor, RAE1 RNA export 1 homolog, homolog of yeast Rae1 mRNA-associated protein of 41 kDa, mRNA export protein, or mRNA-associated protein MRNP 41.

Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by RAE1 is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. RAE1 is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for RAE1 (provided by RefSeq, Jul 2008).

Rabbit anti Human RAE1 antibody detects a band of 41 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.