RABBIT ANTI RAP1A

Rabbit anti Human RAP1A antibody recognizes the Ras-related protein Rap-1A, also known as GTP-binding protein smg p21A and Ras-related protein Krev-1.

The product of RAP1A belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of RAP1A counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for RAP1A (provided by RefSeq, Jul 2008).

Rabbit anti Human RAP1A antibody detects a band of 21 kDa. The antibody has been extensively validated for western blotting using whole cell lysates.